IOF-IFCC Bone Marker Standards Working Group

 

Members

Chairs: C Cooper (IOF) and H Morris (IFCC)

IOF Members: K Åkesson, O Bruyère, R Eastell, N Jorgensen, J Kanis, J Foldes, M McClung, S Silverman

IFCC Members: A Griesmacher, N Lane, T Trenti, S Vasikaran
Co-opted: P Garnero

Aim

This working group seeks to identify consensus reference standard bone resorption marker and bone formation marker for fracture risk assessment and monitoring of osteoporosis treatment. 

Objectives

  1. Identify a consensus reference standard marker for bone resorption (CTX) and for bone formation (P1NP) for fracture risk assessment and monitoring of osteoporosis treatment.
  2. Review the performance of the assays for the standard markers and recommend requirement for standardization of their measurements.
  3. Arrive at a consensus on the diagnostic cut-points and/or action limits for the bone turnover marker assays for intervention and alteration of therapy.
  4. Consult with key international organizations in order to gain international acceptance of the consensus of the WG and its implementation.
  5. Publish guidelines on the use of bone turnover marker assays for fracture risk assessment and monitoring of osteoporosis treatment.
  6. Define research questions that need answers in this area.

Publications

Related content: Bone Turnover Markers Educational Course

https://www.iofbonehealth.org/bone-turnover-markers-educational-course

Clinical usefulness of bone turnover marker concentrations in osteoporosis.

Morris, H., Eastell, R., Jorgensen, N. et al. on behalf of the IFCC-IOF Working Group for Standardisation of Bone Marker Assays.

Clinica Chimica Acta (2017). DOI 10.1016/j.cca.2016.06.036

https://doi.org/10.1016/j.cca.2016.06.036

A Meta-Analysis of Reference Markers of Bone Turnover for Prediction of Fracture.

Johansson, H., Odén, A., Kanis, J. et al. and the IFCC-IOF Joint Working Group on Standardisation of Biochemical Markers of Bone Turnover.

Calcified Tissue International (2014). DOI 10.1007/s00223-014-9842-y

https://link.springer.com/article/10.1007/s00223-014-9842-y

International Osteoporosis Foundation and International Federation of Clinical Chemistry and Laboratory Medicine Position on bone marker standards in osteoporosis.

Vasikaran, S., Cooper, C., Eastell, R. et al.

Clinical Chemistry and Laboratory Medicine (2011). DOI 10.1515/cclm.2011.602

https://doi.org/10.1515/CCLM.2011.602

Recommendations for bone marker standards in osteoporosis: what, why and where to now?

Vasikaran, S., Cooper, C. and Kanis, J.

Annals of Clinical Biochemistry (2011). DOI 10.1258/acb.2011.010286

http://journals.sagepub.com/doi/pdf/10.1258/acb.2011.010286

Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards.

Vasikaran, S., Eastell, R., Bruyère, O. et al. for the IOF-IFCC Bone Marker Standards Working Group.

Osteoporosis International (2010). DOI 10.1007/s00198-010-1501-1

https://link.springer.com/article/10.1007%2Fs00198-010-1501-1