Epidemiology/Quality of Life Working Group


Chairs: JA Kanis and N Harvey
Members: B Abrahamsen, J Adachi, F Borgström, O Bruyère, J Carey, P Clark, E Dennison, M Diaz Curiel, HP Dimai, N Harvey, M Hiligsmann, E Lau, P Lips, M Lewiecki, R Lorenc, E McCloskey, S Ortolani, A Papaioannou, D Prieto-Alhambra, K Sanders, S Silverman, M Sosa, P Szulc, N Yoshimura


To characterise the epidemiology and impact of osteoporosis and its related fragility fractures.


The Epidemiology/Quality of Life Working Group establishes projects which aim to estimate the epidemiology of osteoporosis around the world, to evaluate the impact of fragility fractures on health-related quality of life and finally to measure the direct and indirect cost of osteoporotic fractures worldwide.


  1. Further develop the fracture risk assessment tool (FRAX®) by increasing its international scope and its use in clinical practice.
  2. Provide new data on the global epidemiology and impact of osteoporotic fracture worldwide.
  3. Evaluate the secular changes in fracture incidence rates worldwide
  4. Estimate the cost and quality of life following a hip fracture, a vertebral fracture and a wrist fracture in different countries, through the International Cost and Utilities Related to Osteoporotic fractures Study (ICUROS).
  5. Osteoporosis treatment pathway model: Development of an economic  simulation model that refelcts the treatment pathway of osteoporosis
  6. Oldest old initiative: To study how treatment effectiveness and risk factors behave in the Oldest Old compared with younger populations. (O. Ström, F. Borgström. K. Åkesson, Ö. Ljunggren, and A. Spångeus)

Managing treatment cessation - subgroup Epi/QoL

Chair: S Ferrari
Members: J Adachi, E Dennison, M Lewiecki, E McCloskey, D Prieto-Alhambra, S Silverman

  1. Systematic review
  2. Algorithm


A systematic review of intervention thresholds based on FRAX : A report prepared for the National Osteoporosis Guideline Group and the International Osteoporosis Foundation. Kanis JA, Harvey NC, Cooper C, Johansson H, Odén A, McCloskey EV; Advisory Board of the National Osteoporosis Guideline Group. Arch Osteoporos. 2016 11:25. doi: 10.1007/s11657-016-0278-z.

Bisphosphonate drug holidays: we reap what we sow. S. L. Silverman,  J. D. Adachi, E. Dennison & And the International Osteoporosis Foundation Epidemiology/Quality of Life Working Group. Osteoporos Int DOI 10.1007/s00198-015-3453-y

Quality of life, resource use, and costs related to hip fracture in Estonia Jürisson M, Pisarev H, Kanis J, Borgström F, Svedbom A, Kallikorm R, Lember M, Uusküla A Osteoporos Int. 2016;27:2555-66. doi: 10.1007/s00198-016-3544-4.

Changes in quality of life associated with fragility fractures: Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS). Abimanyi-Ochom J, Watts JJ, Borgström F, Nicholson GC, Shore-Lorenti C, Stuart AL, Zhang Y, Iuliano S, Seeman E, Prince R, March L, Cross M, Winzenberg T, Laslett LL, Duque G, Ebeling PR, Sanders KM. Osteoporos Int. 2015; 26:1781-90. doi: 10.1007/s00198-015-3088-z.

Worldwide uptake of FRAX.  Kanis JA, Johansson H, Oden A, Cooper C, McCloskey EV, and the Epidemiology and Quality of Life Working Group of  IOF. Archives of Osteoporosis Arch Osteoporos (2014) 9:166 DOI 10.1007/s11657-013-0166-8

Standardizing the descriptive epidemiology of osteoporosis: recommendations from the Epidemiology and Quality of Life Working Group of IOF. Kanis JA, Adachi JD, Cooper C, Clark P, Cummings S.R., Diaz-Curiel M, Harvey N, Hiligsmann M, Papaoiannou A, Pierroz DD, Silverman SL, Szulc P. The Epidemiology and Quality of Life Working Group of IOF. Osteoporos Int. 2013;24:2763-4. doi: 10.1007/s00198-013-2413-7

The International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS) - quality of life during the first 4 months after fracture. Borgstrom F, Lekander I, Ivergard M, Strom O, Svedbom A, Alekna V, Bianchi ML, Clark P, Curiel MD, Dimai HP, Jurisson M, Kallikorm R, Lesnyak O, McCloskey E, Nassonov E, Sanders KM, Silverman S, Tamulaitiene M, Thomas T, Tosteson ANA, Jonsson B, Kanis JA. Osteoporosis Int 2013;24(3):811-23.

Economic burden of osteoporotic fractures in Austria. Dimai HP, Redlich K, Peretz M, Borgström F, Siebert U, Mahlich J. Health Econ Rev. 2012;2:12. doi: 10.1186/2191-1991-2-12.

A systematic review of hip fracture incidence and probability of fracture worldwide. Kanis JA, Oden A, McCloskey EV, Johansson H, Wahl DA, Cooper C; IOF Working Group on Epidemiology and Quality of Life. Osteoporosis Int 2012;23(9):2239-56.

Validation of the IOF quality of life questionnaire for patients with wrist fracture (PDF, 198 KB)
P.Lips, K. Jameson, M.L. Bianchi et al. Working Group for Quality of Life of the International Osteoporosis Foundation. Osteoporosis International. DOI 10.1007/s00198-009-0946-6

Secular trends in the incidence of hip and other osteoporotic fractures
Cooper C, Cole, ZA, Holroyd CR et al (2011)
Osteoporosis International. Volume 22, Number 5, 1277-1288, DOI: 10.1007/s00198-011-1601-6